Figure 2.

Inhibition of MIR22HG accelerated cell proliferation and suppressed apoptosis and cartilage matrix degeneration in IL-1β-induced chondrocyte. (a)The silence efficiency of si-MIR22HG were detected using qRT-PCR. CCK8, flow cytometry, qRT-PCR, and western blot were employed to measure chondrocyte proliferation(b), apoptotic (c, d), and the mRNA(e) and protein(f) expression level of COL2A1, ACAN, MMP13, ADAMTS5 in IL-1β-stimulated chondrocyte. The results are shown as the mean ± SEM of at least three independent experiments (*P < 0.05)