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. 2021 Aug 4;12(1):4828–4840. doi: 10.1080/21655979.2021.1955559

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Relationships between Rap1b, MMRs deficiency and DNA methylation level in different cancers. (a) The relationship between the Rap1b expression of five important MMR related genes (MLH1, MSH2, MSH6, PMS2, EPCAM). The lower triangle of each tile represents the coefficient calculated by Pearson correlation test, and the upper triangle represents the P-value after log10 transformation. *P < 0. 05, **P < 0. 01, ***P < 0.001. (b) The relationship between Rap1b and four methyltransferases (DNMT1: red, DNMT2: blue, DNMT3A: green, DNMT3b: purple)