Figure 6.

Rhein lowed the expression levels of ERs-related proteins and ATG5 levels. n = 6 rats/group. The rats of different groups received the following treatment for six weeks, respectively. normal chow, high-fat diet (HFD) (D12492, 60% kcal%, Research Diets, USA), high-fat diet +Rhein-L (lose dose), high-fat diet (60% kcal%) + Rhein-M (medium dose), high-fat diet (60% kcal%) +Rhein-H (high dose). HFD, high-fat diet-fed rats. ***p < 0.001 versus control. #p < 0.05, ##p < 0.01, ###p < 0.001 versus HFD