Figure 10.

Effects of rhein on ER stress of adipose tissue in SD rats fed with HFD. western blot analysis of adipose tissue showing the expression of ERs-related protein and ATG5. The rats of different groups received the following treatment for six weeks, respectively. normal chow, high-fat diet (HFD) (D12492, 60% kcal%, Research Diets, USA), high-fat diet +Rhein-L (lose dose), high-fat diet (60% kcal%) + Rhein-M (medium dose), high-fat diet (60% kcal%) +Rhein-H (high dose). n = 6 rats/group. HFD, high-fat diet-fed rats. ***p < 0.05 versus control. ##p < 0.01, ###p < 0.001 versus HFD