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. 2021 Aug 19;12(1):5305–5322. doi: 10.1080/21655979.2021.1964889

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — EGR1 transcriptionally activates miR-675 to govern SESN3 expression. a, differentially expressed miRNAs in cells transfected with si-EGR1 determined using a miRNA microarray analysis; b, binding between EGR1 and miR-675 promoter validated via the ChIP-qPCR assay (two-way ANOVA, *p < 0.05); c, a Venn map for the intersection of the predicted mRNA targets of miR-675 and the differentially expressed mRNAs of the two GEO datasets; d, mRNA expression of SESN3 in HLE and Hep3B cells after si-EGR1 transfection examined by RT-qPCR (two-way ANOVA, *p < 0.05); e, binding between miR-675 and SESN3 validated via a luciferase assay (two-way ANOVA, *p < 0.05); f, miR-675 and SESN3 expression in the LC cell lines (Huh-7, HLE, Hep3B and MHCC97-H) and in THLE-3 cells quantified by RT-qPCR (two-way ANOVA, *#p < 0.05); g, expression of miR-675 and SESN3 mRNA in the LC tissues and the para-cancerous tissues examined by RT-qPCR (n = 43, the paired t test)