Figure 8.

The EGR1/miR-675/SESN3 axis mediates the Wnt/β-catenin pathway. a-b, abnormally activated signaling pathways in LC analyzed by KEGG pathway analyses based on the genes screened using the GSE101728 (a) and GSE138178 (b) datasets, and the top 10 pathways were presented (* p < 0.05, Fisher’s exact test); c, a Venn map for the intersected pathways in panels a and b; d, a KEGG enrichment analysis based on the targeting genes of miR-675, and the top 10 pathways were presented (Fisher’s exact test, *p < 0.05); e-f, protein levels of β-catenin and c-myc in HLE (e) and Hep3B (f) cells examined by western blot analysis (two-way ANOVA, *p < 0.05 vs. EGR1-NC, #p < 0.05 vs. si-EGR1 + miR-675, &p < 0.05 vs miR-675+ SESN3)