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. 2021 Sep 14;12(1):6713–6723. doi: 10.1080/21655979.2021.1971484

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — FGD5-AS1 regulates DDP resistance in DDP-resistant HCC cells by targeting miR-153-3p expression. (a) RT-qPCR was used to determine relative FGD5-AS1 expression in Huh7/DDP and Hep3B/DDP cells transfected with pcDNA3.1 or pcDNA3.1/FGD5-AS1. (b) RT-qPCR was used to analyze relative miR-153-3p expression in DDP-resistant HCC cells transfected with NC mimic, miR-153-3p mimic and miR-153-3p mimic + pcDNA3.1/FGD5-AS1. (c) CCK-8 assay was used to determine the IC₅₀ value of DDP in Huh7/DDP and Hep3B/DDP cells transfected with NC mimic, miR-153-3p mimic and miR-153-3p mimic + pcDNA3.1/FGD5-AS1. (d and e) CCK-8, (f) colony formation, (g) Transwell and (h) TUNEL assays were used to analyze the proliferation, invasion and apoptosis, respectively, of Huh7/DDP and Hep3B/DDP cells transfected with NC mimic, miR-153-3p mimic and miR-153-3p mimic + pcDNA3.1/FGD5-AS1. *P < 0.05