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. 2021 Sep 4;12(1):6186–6200. doi: 10.1080/21655979.2021.1973874

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Inhibiting the expression of AL161431.1 blocks LUAD cell proliferation. (a) The mRNA expression level of seven signature lncRNAs in BEAS-2B and two LUAD cell lines (b) Relative expression of AL161431.1 in LUAD tissues and adjacent normal tissues. (c) AL161431.1was upregulated in A549 cells by hypoxia treatment. (d) AL161431.1 was inhibited in A549 using siRNAs. The effect of AL161431.1 on proliferation in A549 was detected using CCK-8 (e) and colony formation assays (f). (g) Transwell assays for cell migration (Scale bars: 100 μm). (h) Flow cytometric analysis of A549 cells transfected with siRNAs or si-NC about apoptotic rates. (i) Venn diagram showed the downstream target miRNAs of AL161431.1 by starbase and DIANA database. (j) The expression of three predicated miRNAs by qRT-PCR. (k) Luciferase assay in A549 cells after co-transfected either AL161431.1-wt or AL161431.1-mut vectors with miR-1252-5p mimic (*p < 0.05; **p < 0.01; ***p < 0.001)