Table 2.
Top-ranked KEGG pathways obtained related to DEMs metabolites in between three groups
| Pathways |
Pathway Codes |
Total Metabolites |
Differential Metabolites |
Impact Scores |
P value |
|---|---|---|---|---|---|
| PCOS vs CTRL | |||||
| cAMP signaling pathway | hsa04024 | 25 | 3 | 0.11111 | 0.0040728 |
| Pathways in cancer | hsa05200 | 31 | 3 | 0.090909 | 0.0075314 |
| Prostate cancer | hsa05215 | 11 | 2 | 0.23077 | 0.0087473 |
| Synaptic vesicle cycle | hsa04721 | 12 | 2 | 0.16667 | 0.010409 |
| Central carbon metabolism in cancer | hsa05230 | 37 | 3 | 0.09434 | 0.01232 |
| Salivary secretion | hsa04970 | 17 | 2 | 0.10526 | 0.020568 |
| Protein digestion and absorption | hsa04974 | 47 | 3 | 0.06383 | 0.02346 |
| Intestinal immune network for IgA production | hsa04672 | 2 | 1 | 0.5 | 0.026326 |
| Citrate cycle (TCA cycle) | hsa00020 | 20 | 2 | 0.11667 | 0.028023 |
| ABC transporters | hsa02010 | 138 | 5 | 0.11111 | 0.034032 |
| POF vs CTRL | |||||
| ABC transporters | hsa02010 | 138 | 19 | 0.13768 | 3.00E-05 |
| Protein digestion and absorption | hsa04974 | 47 | 10 | 0.21277 | 6.59E-05 |
| Central carbon metabolism in cancer | hsa05230 | 37 | 8 | 0.16981 | 0.00032311 |
| Mineral absorption | hsa04978 | 29 | 7 | 0.2 | 0.00037662 |
| Cortisol synthesis and secretion | hsa04927 | 12 | 4 | 0.33333 | 0.0020315 |
| Cushing syndrome | hsa04934 | 13 | 4 | 0.31579 | 0.0028231 |
| Arginine and proline metabolism | hsa00330 | 78 | 10 | 0.38725 | 0.004285 |
| Valine, leucine and isoleucine biosynthesis | hsa00290 | 23 | 5 | 0.29032 | 0.0043849 |
| GABAergic synapse | hsa04727 | 9 | 3 | 0.41176 | 0.0078337 |
| Glutathione metabolism | hsa00480 | 38 | 6 | 0.18531 | 0.0095182 |
| PCOS vs POF | |||||
| Protein digestion and absorption | hsa04974 | 47 | 15 | 0.31915 | 1.01E-08 |
| ABC transporters | hsa02010 | 138 | 24 | 0.17391 | 2.07E-07 |
| Central carbon metabolism in cancer | hsa05230 | 37 | 11 | 0.24528 | 2.30E-06 |
| Aminoacyl-tRNA biosynthesis | hsa00970 | 52 | 11 | 0.21429 | 7.89E-05 |
| Prostate cancer | hsa05215 | 11 | 5 | 0.46154 | 0.00016079 |
| Pathways in cancer | hsa05200 | 31 | 8 | 0.24242 | 0.00017828 |
| Ovarian steroidogenesis | hsa04913 | 24 | 7 | 0.29545 | 0.00019958 |
| Mineral absorption | hsa04978 | 29 | 7 | 0.2 | 0.00071327 |
| GABAergic synapse | hsa04727 | 9 | 4 | 0.64706 | 0.00086673 |
| Taste transduction | hsa04742 | 32 | 7 | 0.23684 | 0.0013384 |