Figure 4.

CUL3 overexpression promotes inflammation and apoptosis of PDLSCs treated with pg-LPS. (a) ELISA assay was performed to detect the effect of CUL3 overexpression on inflammatory factors (TNF-α, IL-6, IL-1β and IL-10) in PDLSCs treated with 1 μg/mL pg-LPS. (b) Tunel assay was performed to detected the effect of CUL3 overexpression on apoptosis of PDLSCs treated with 1 μg/mL pg-LPS. Magnification×200. (c) Statistical analysis of apoptosis. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. pcDNA-NC. ***p < 0.001 vs Control, ##p < 0.01, ###p < 0.001 vs LPS+pcDNA-NC. CUL3: Cullin3.CUL3: Cullin3