Table 2.

Diagnostic test accuracy of the EUROIMMUN interferon-γ release assay using different cut-offs at an estimated COVID-19 disease prevalence of 10%.

	Cut-off >100 mIU/ml	Cut-off ≥200 mIU/ml	Adapted cut-off*
Sensitivity% (95% CI)	89.6 (82.2 – 94.7)	72.2 (61.8 – 81.2)	86.8 (78.8 – 92.6)
Specificity	96.2 (86.8 – 99.5)	100.0 (93,2.7 – 100,0)	100 (93.2 – 100,0)
Negative predictive value	98.8 (97.9 – 99.3)	97.1 (95.9 – 97.8)	98.6 (97.7 – 99.1)
Positive predictive value	72.2 (39.9 – 90.9)	100,0	100,0
Accuracy	95.5 (90.9 – 98.2)	97.2 (93.0 – 99.2)	98.7 (95.4 – 99.8)

^⁎Adapted cut-off: Cut-off ≥135 mIU/ml if BLANK < 100 mIU/ml and ≥200 mIU/ml if BLANK ≥100 mIU/ml mIU/ml.