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. 2021 Oct 18;12(1):8407–8418. doi: 10.1080/21655979.2021.1977556

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Downregulation of cyclin D1 and c-myc by miR-130a-3p overexpression. (a-b) RT-qPCR was performed to measure the mRNA expression of cyclin D1 and c-myc in human CRC tissues and normal colon tissues. (c-f) Western blotting for determining Cyclin D1 and c-myc protein expression in control, mimic control, and mimic transfection CRC cell groups. (g-j) RT-qPCR results. Reduction of cyclin D1 and c-myc in CRC cell lines by miR-130a-3p overexpression (mimics group), compared with control and mimics control groups. CRC, colorectal cancer. *P < 0.05, **P < 0.01