Figure 3.

CXCR4, a hub gene from the PPI network, correlated with STAD prognosis and was identified as a target gene of triptolide. (3a) PPI network (STRING) based on DEGs (combined score = 0.95). (3b) Interaction network constructed using Cytoscape v3.7.2 based on DEGs with a minimum required interaction score > 0.95; green and red illustrate downregulated and upregulated genes, respectively. (3 c) Sub-network of 30 hub genes filtered by Cytohubba MCC method; node score increases from light to dark color. (3d) Forest plot of Cox regression analysis with DEGs; genes with p < 0.05 and HR > 1 were identified as high-risk factors for STAD prognosis. (3e) Venn diagram of 30 hub genes from the PPI network, 42 prognosis-related genes based on Cox regression analysis, and 34 target genes of triptolide