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. 2021 Aug 4;12(1):4304–4319. doi: 10.1080/21655979.2021.1945522

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Comparison between CXCR4 expression with prognosis/clinicopathological features in STAD patients. (4a, 4b) Difference analysis and paired difference analysis showed significantly higher CXCR4 expression levels in STAD tissues versus normal tissues (p < 0.05, Wilcoxon test). (4 c) Patients were categorized into CXCR4 high-/low-expressing cohorts; survival curve showed that CXCR4 was linked to poor prognosis of STAD patients (p = 0.003). (4d) CXCR4 expression levels were significantly higher in T2/3/4 versus T1 and in T4 versus T2 (p < 0.05). (4e) No correlation detected between CXCR4 expression and N classification (p > 0.05). (4 f) CXCR4 showed no difference between patients with and without metastasis (p = 0.059)