Table 3.
List of 15 cancer- and CXCR4-related KEGG pathways significantly enriched by 34 targets of triptolide
| KEGG pathway | Gene ratio | q value |
|---|---|---|
| Toll-like receptor signaling pathway | 11/34 | 1.49E-12 |
| NF-kappa B signaling pathway | 10/34 | 2.90E-11 |
| Pancreatic cancer | 8/34 | 1.57E-09 |
| Colorectal cancer | 8/34 | 3.74E-09 |
| Small cell lung cancer | 8/34 | 5.71E-09 |
| T cell receptor signaling pathway | 8/34 | 1.32E-08 |
| TNF signaling pathway | 8/34 | 2.24E-08 |
| JAK-STAT signaling pathway | 9/34 | 2.24E-08 |
| Platinum drug resistance | 6/34 | 5.34E-07 |
| HIF-1 signaling pathway | 6/34 | 4.61E-06 |
| Bladder cancer | 4/34 | 1.86E-05 |
| Prostate cancer | 5/34 | 3.65E-05 |
| Chemokine signaling pathway | 6/34 | 8.79E-05 |
| Renal cell carcinoma | 4/34 | 0.00012 |
| p53 signaling pathway | 4/34 | 0.000146 |
Abbreviations: KEGG, Kyoto Encyclopedia of Genes and Genomes.