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CircCRKL is down-expressed in AML samples and cell lines. (a) the expression of circCRKL in the AML samples (N = 34) and normal healthy samples (N = 34). (b) the expression of circCRKL in the HS-5 and AML cell lines (KG-1a, KG-1, kasumi-1, THP1 and MOLM13). (c, d) qRT-PCR analysis of the circCRKL expression in THP1 and MOLM13 cells after RNase R treatmet. (e, f) the circCRKL distribution was identified via the RNA nucleus/cytoplasm separation assay. **P < 0.01, ***P < 0.001
