Figure 4.

XIST targets miR-29b-3p.(a) Schematic diagram of predicted binding sites of XIST in 3’-UTR of miR-29b-3p. (b) Determination of the dual-luciferase activity of BMSCs transfected with XIST-MUT or XIST-WT and agomiR-NC or agomiR miR-29b-3p. ** P < 0.001 vs. agomiR-NC. (c) The expression of miR-29b-3p in the serum of OP patients and non-OP patients. ** P < 0.001. (d) Pearson analysis of correlation between miR-29b-3p and XIST in the serum of OP patients. (e) The expression of miR-29b-3p in BMSCs after transfection of sh-XIST 2#

** P < 0.001 vs. blank.