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Behavioral deficits in I/R injured diabetic mice were ameliorated by ibrutinib in a dose-dependent manner. (a) Neurological deficit assessment, (b) forepaw adhesive removal tests, (c) beam walk tests, and (d) rotarod tests showed improvement with ibrutinib in a slightly dose-dependent manner three days after I/R injury. Data presented as mean SD, n = 6/group. *P < 0.05 vs. the DS group, #P < 0.05 vs. the DIR group
