Table 3.
GO functional annotation of the three-gene signature
| Category | ID | GO term | P-value | Gene |
|---|---|---|---|---|
| BP | GO:0071347 | cellular response to interleukin-1 | 0.00014 | CCL20, IL1R2 |
| BP | GO:0070555 | response to interleukin-1 | 0.00020 | CCL20, IL1R2 |
| BP | GO:0050711 | negative regulation of interleukin-1 secretion | 0.0025 | IL1R2 |
| BP | GO:1900016 | negative regulation of cytokine production involved in inflammatory response | 0.0031 | IL1R2 |
| BP | GO:0035584 | calcium-mediated signaling using intracellular calcium source | 0.0035 | CCL20 |
| BP | GO:0032692 | negative regulation of interleukin-1 production | 0.0045 | IL1R2 |
| BP | GO:2000406 | positive regulation of T cell migration | 0.0048 | CCL20 |
| BP | GO:0070207 | protein homotrimerization | 0.0052 | ITLN1 |
| BP | GO:0046326 | positive regulation of glucose import | 0.0053 | ITLN1 |
| BP | GO:2000403 | positive regulation of lymphocyte migration | 0.0058 | CCL20 |
| BP | GO:0010955 | negative regulation of protein processing | 0.0061 | IL1R2 |
| BP | GO:1903318 | negative regulation of protein maturation | 0.0061 | IL1R2 |
| BP | GO:0010828 | positive regulation of glucose transmembrane transport | 0.0064 | ITLN1 |
| BP | GO:1900015 | regulation of cytokine production involved in inflammatory response | 0.0064 | IL1R2 |
| BP | GO:2000404 | regulation of T cell migration | 0.0064 | CCL20 |
| BP | GO:0002534 | cytokine production involved in inflammatory response | 0.0069 | IL1R2 |
| BP | GO:0050704 | regulation of interleukin-1 secretion | 0.0079 | IL1R2 |
| BP | GO:0070206 | protein trimerization | 0.0087 | ITLN1 |
| BP | GO:0046324 | regulation of glucose import | 0.0088 | ITLN1 |
| BP | GO:0070498 | interleukin-1-mediated signaling pathway | 0.0088 | IL1R2 |
| BP | GO:0001960 | negative regulation of cytokine-mediated signaling pathway | 0.0090 | IL1R2 |
| BP | GO:0050701 | interleukin-1 secretion | 0.0090 | IL1R2 |
| BP | GO:0072678 | T cell migration | 0.0095 | CCL20 |
| BP | GO:2000401 | regulation of lymphocyte migration | 0.0095 | CCL20 |
| BP | GO:0060761 | negative regulation of response to cytokine stimulus | 0.0097 | IL1R2 |
| BP | GO:0002532 | production of molecular mediator involved in inflammatory response | 0.010 | IL1R2 |
| BP | GO:0046323 | glucose import | 0.010 | ITLN1 |
| BP | GO:0048247 | lymphocyte chemotaxis | 0.010 | CCL20 |
| BP | GO:0002548 | monocyte chemotaxis | 0.010 | CCL20 |
| BP | GO:0050710 | negative regulation of cytokine secretion | 0.010 | IL1R2 |
| BP | GO:0010827 | regulation of glucose transmembrane transport | 0.011 | ITLN1 |
| BP | GO:0032652 | regulation of interleukin-1 production | 0.012 | IL1R2 |
| BP | GO:0071674 | mononuclear cell migration | 0.013 | CCL20 |
| BP | GO:0032612 | interleukin-1 production | 0.014 | IL1R2 |
| BP | GO:0070098 | chemokine-mediated signaling pathway | 0.014 | CCL20 |
| BP | GO:1990868 | response to chemokine | 0.015 | CCL20 |
| BP | GO:1990869 | cellular response to chemokine | 0.015 | CCL20 |
| BP | GO:0030593 | neutrophil chemotaxis | 0.016 | CCL20 |
| BP | GO:1904659 | glucose transmembrane transport | 0.016 | ITLN1 |
| BP | GO:0072676 | lymphocyte migration | 0.016 | CCL20 |
| BP | GO:0008645 | hexose transmembrane transport | 0.017 | ITLN1 |
| BP | GO:0015749 | monosaccharide transmembrane transport | 0.017 | ITLN1 |
| BP | GO:0034219 | carbohydrate transmembrane transport | 0.018 | ITLN1 |
| BP | GO:1990266 | neutrophil migration | 0.018 | CCL20 |
| BP | GO:0019730 | antimicrobial humoral response | 0.019 | ITLN1 |
| BP | GO:0071621 | granulocyte chemotaxis | 0.019 | CCL20 |
| BP | GO:0002687 | positive regulation of leukocyte migration | 0.019 | CCL20 |
| BP | GO:0050709 | negative regulation of protein secretion | 0.020 | IL1R2 |
| BP | GO:0097530 | granulocyte migration | 0.021 | CCL20 |
| BP | GO:0002792 | negative regulation of peptide secretion | 0.021 | IL1R2 |
| BP | GO:0050728 | negative regulation of inflammatory response | 0.022 | IL1R2 |
| BP | GO:0008643 | carbohydrate transport | 0.022 | ITLN1 |
| BP | GO:0001959 | regulation of cytokine-mediated signaling pathway | 0.024 | IL1R2 |
| BP | GO:0060759 | regulation of response to cytokine stimulus | 0.026 | IL1R2 |
| BP | GO:0070613 | regulation of protein processing | 0.027 | IL1R2 |
| BP | GO:1903317 | regulation of protein maturation | 0.027 | IL1R2 |
| BP | GO:0071346 | cellular response to interferon-gamma | 0.028 | CCL20 |
| BP | GO:0002685 | regulation of leukocyte migration | 0.028 | CCL20 |
| BP | GO:0051224 | negative regulation of protein transport | 0.029 | IL1R2 |
| BP | GO:0050707 | regulation of cytokine secretion | 0.029 | IL1R2 |
| BP | GO:1904950 | negative regulation of establishment of protein localization | 0.029 | IL1R2 |
| BP | GO:0034764 | positive regulation of transmembrane transport | 0.030 | ITLN1 |
| BP | GO:1903531 | negative regulation of secretion by cell | 0.031 | IL1R2 |
| BP | GO:0034341 | response to interferon-gamma | 0.031 | CCL20 |
| BP | GO:0031348 | negative regulation of defense response | 0.031 | IL1R2 |
| BP | GO:0097529 | myeloid leukocyte migration | 0.031 | CCL20 |
| BP | GO:0050663 | cytokine secretion | 0.033 | IL1R2 |
| BP | GO:0030595 | leukocyte chemotaxis | 0.034 | CCL20 |
| BP | GO:0019722 | calcium-mediated signaling | 0.035 | CCL20 |
| BP | GO:0051048 | negative regulation of secretion | 0.035 | IL1R2 |
| BP | GO:0071356 | cellular response to tumor necrosis factor | 0.037 | CCL20 |
| MF | GO:0070492 | oligosaccharide binding | 0.0025 | ITLN1 |
| MF | GO:0048020 | CCR chemokine receptor binding | 0.0072 | CCL20 |
| MF | GO:0008009 | chemokine activity | 0.0083 | CCL20 |
| MF | GO:0042379 | chemokine receptor binding | 0.011 | CCL20 |
| MF | GO:0004896 | cytokine receptor activity | 0.015 | IL1R2 |
| MF | GO:0019955 | cytokine binding | 0.021 | IL1R2 |
| MF | GO:0019838 | growth factor binding | 0.023 | IL1R2 |