Table 1.
GO enrichment terms of genes associated with AMI
| ONTOLOGY | ID | Description | p.adjust | qvalue | geneID |
|---|---|---|---|---|---|
| BP | GO:0034329 | cell junction assembly | 0.009006759 | 0.008184047 | LIMS2, FN1, FAM107A, EFNA5, NRP1, CTNND1, FERMT2, TJP1, CDH5, CDH13, GJC1, JUP |
| BP | GO:1,901,342 | regulation of vasculature development | 0.009006759 | 0.008184047 | CD34, CYP1B1, PLK2, ECSCR, SASH1, MEOX2, HEY1, DAB2IP, NRP1, CDH5, JUP, PTPRM |
| BP | GO:0045216 | cell-cell junction organization | 0.009006759 | 0.008184047 | LIMS2, CTNND1, RASSF8, TJP1, CDH5, CDH13, GJC1, JUP |
| BP | GO:0045765 | regulation of angiogenesis | 0.009006759 | 0.008184047 | CD34, CYP1B1, PLK2, ECSCR, SASH1, MEOX2, DAB2IP, NRP1, CDH5, JUP, PTPRM |
| BP | GO:0001667 | ameboidal-type cell migration | 0.009006759 | 0.008184047 | CYP1B1, FN1, PLK2, SASH1, MEOX2, DAB2IP, NRP1, EDNRB, CDH13, KRT16, JUP, PTPRM |
| BP | GO:0043542 | endothelial cell migration | 0.012115814 | 0.011009109 | CYP1B1, PLK2, SASH1, MEOX2, DAB2IP, NRP1, CDH13, JUP, PTPRM |
| BP | GO:0034332 | adherens junction organization | 0.012115814 | 0.011009109 | CTNND1, RASSF8, CDH5, CDH13, JUP |
| BP | GO:0010631 | epithelial cell migration | 0.012115814 | 0.011009109 | CYP1B1, PLK2, SASH1, MEOX2, DAB2IP, NRP1, CDH13, KRT16, JUP, PTPRM |
| BP | GO:0090132 | epithelium migration | 0.012115814 | 0.011009109 | CYP1B1, PLK2, SASH1, MEOX2, DAB2IP, NRP1, CDH13, KRT16, JUP, PTPRM |
| BP | GO:0090130 | tissue migration | 0.012115814 | 0.011009109 | CYP1B1, PLK2, SASH1, MEOX2, DAB2IP, NRP1, CDH13, KRT16, JUP, PTPRM |
| BP | GO:0007160 | cell-matrix adhesion | 0.012115814 | 0.011009109 | CD34, FN1, FAM107A, EFNA5, NRP1, FERMT2, CDH13, JUP |
| BP | GO:0090136 | epithelial cell-cell adhesion | 0.015809313 | 0.014365229 | CYP1B1, JUP, SERPINB8 |
| BP | GO:0040013 | negative regulation of locomotion | 0.015814018 | 0.014369505 | CYP1B1, IGFBP5, DPYSL3, MEOX2, DAB2IP, NRP1, DACH1, KRT16, JUP, PTPRM |
| BP | GO:0051271 | negative regulation of cellular component movement | 0.015814018 | 0.014369505 | CYP1B1, IGFBP5, DPYSL3, MEOX2, DAB2IP, NRP1, DACH1, KRT16, JUP, PTPRM |
| BP | GO:0007043 | cell-cell junction assembly | 0.017748541 | 0.016127321 | CTNND1, TJP1, CDH5, CDH13, GJC1, JUP |
| BP | GO:0003158 | endothelium development | 0.01887607 | 0.017151857 | CD34, HEY1, ZEB1, NRP1, TJP1, CDH5 |
| BP | GO:0030336 | negative regulation of cell migration | 0.022636214 | 0.020568535 | CYP1B1, IGFBP5, DPYSL3, MEOX2, DAB2IP, DACH1, KRT16, JUP, PTPRM |
| BP | GO:0045766 | positive regulation of angiogenesis | 0.026799299 | 0.024351348 | CD34, CYP1B1, PLK2, SASH1, NRP1, CDH5, JUP |
| BP | GO:2,000,146 | negative regulation of cell motility | 0.02683029 | 0.024379507 | CYP1B1, IGFBP5, DPYSL3, MEOX2, DAB2IP, DACH1, KRT16, JUP, PTPRM |
| BP | GO:0031290 | retinal ganglion cell axon guidance | 0.02683029 | 0.024379507 | EFNA5, NRP1, PTPRM |
| BP | GO:0031589 | cell-substrate adhesion | 0.02683029 | 0.024379507 | CD34, LIMS2, FN1, FAM107A, EFNA5, NRP1, FERMT2, CDH13, JUP |
| BP | GO:0007044 | cell-substrate junction assembly | 0.02683029 | 0.024379507 | FN1, FAM107A, EFNA5, NRP1, FERMT2 |
| BP | GO:0150115 | cell-substrate junction organization | 0.02683029 | 0.024379507 | FN1, FAM107A, EFNA5, NRP1, FERMT2 |
| BP | GO:0010810 | regulation of cell-substrate adhesion | 0.026892301 | 0.024435855 | LIMS2, FN1, FAM107A, EFNA5, NRP1, CDH13, JUP |
| BP | GO:0051017 | actin filament bundle assembly | 0.026892301 | 0.024435855 | FAM107A, SYNPO, DPYSL3, BAIAP2L1, AIF1L, NRP1 |
| BP | GO:0034446 | substrate adhesion-dependent cell spreading | 0.027335382 | 0.024838463 | LIMS2, FN1, EFNA5, NRP1, FERMT2 |
| BP | GO:0061572 | actin filament bundle organization | 0.028586963 | 0.02597572 | FAM107A, SYNPO, DPYSL3, BAIAP2L1, AIF1L, NRP1 |
| BP | GO:0010594 | regulation of endothelial cell migration | 0.034323026 | 0.031187828 | PLK2, SASH1, MEOX2, DAB2IP, NRP1, JUP, PTPRM |
| BP | GO:1,904,018 | positive regulation of vasculature development | 0.034323026 | 0.031187828 | CD34, CYP1B1, PLK2, SASH1, NRP1, CDH5, JUP |
| BP | GO:0072330 | monocarboxylic acid biosynthetic process | 0.039658473 | 0.036035915 | PDK4, LPL, IDO1, FABP5, BGN, FADS6, OSBPL1A |
| BP | GO:0045446 | endothelial cell differentiation | 0.041833964 | 0.038012688 | HEY1, ZEB1, NRP1, TJP1, CDH5 |
| BP | GO:0048871 | multicellular organismal homeostasis | 0.04501582 | 0.040903902 | CD34, EPAS1, WWTR1, LDB2, PDK4, FABP5, FABP4, EDNRB, ZNF423, KRT16 |
| BP | GO:0001952 | regulation of cell-matrix adhesion | 0.047747232 | 0.043385816 | FAM107A, EFNA5, NRP1, CDH13, JUP |
| BP | GO:0010811 | positive regulation of cell-substrate adhesion | 0.049966936 | 0.045402763 | LIMS2, FN1, NRP1, CDH13, JUP |
| CC | GO:0005925 | focal adhesion | 8.38E-05 | 6.67E-05 | ENAH, LIMS2, ARHGAP31, FAM107A, EPB41 L2, AIF1L, NRP1, PPFIBP1, FERMT2, SLC9A3R2, CDH13, JUP, TGM2 |
| CC | GO:0030055 | cell-substrate junction | 8.38E-05 | 6.67E-05 | ENAH, LIMS2, ARHGAP31, FAM107A, EPB41 L2, AIF1L, NRP1, PPFIBP1, FERMT2, SLC9A3R2, CDH13, JUP, TGM2 |
| CC | GO:0030027 | lamellipodium | 0.000948734 | 0.000755338 | ENAH, FGD5, ARHGAP31, APBB2, DPYSL3, CTNND1, FERMT2, PTPRM |
| CC | GO:0016342 | catenin complex | 0.000948734 | 0.000755338 | CTNND1, CDH5, CDH13, JUP |
| CC | GO:0031252 | cell leading edge | 0.000948734 | 0.000755338 | ENAH, FGD5, ARHGAP31, FAM107A, LDB2, APBB2, DPYSL3, AIF1L, CTNND1, FERMT2, PTPRM |
| CC | GO:0005911 | cell-cell junction | 0.001056975 | 0.000841514 | LIMS2, SYNPO, EFNA5, MPDZ, TMEM47, CTNND1, TJP1, CDH5, GJC1, JUP, PTPRM |
| CC | GO:0043296 | apical junction complex | 0.005423338 | 0.004317806 | SYNPO, MPDZ, CTNND1, TJP1, CDH5, JUP |
| CC | GO:0062023 | collagen-containing extracellular matrix | 0.015437633 | 0.012290715 | FN1, SPARCL1, EFNA5, BGN, A2M, MGP, CDH13, SERPINB8, TGM2 |
| CC | GO:0005912 | adherens junction | 0.022320104 | 0.017770213 | EFNA5, TMEM47, CTNND1, JUP |
| CC | GO:0045177 | apical part of cell | 0.036690671 | 0.029211381 | CD34, FN1, CLIC5, GPIHBP1, MPDZ, TJP1, SLC9A3R2, ATP8B1 |
| CC | GO:0043292 | contractile fiber | 0.042863184 | 0.034125645 | TIMP4, SYNPO, IDO1, TNNT3, FERMT2, JUP |
| CC | GO:0016324 | apical plasma membrane | 0.042863184 | 0.034125645 | CD34, FN1, CLIC5, GPIHBP1, MPDZ, SLC9A3R2, ATP8B1 |
| CC | GO:0019897 | extrinsic component of plasma membrane | 0.042863184 | 0.034125645 | CTNND1, FERMT2, CDH5, CDH13, JUP |
| MF | GO:0045296 | cadherin binding | 0.000192766 | 0.000171861 | BAIAP2L1, NDRG1, DAB2IP, CTNND1, PPFIBP1, STXBP6, TJP1, SLC9A3R2, CDH5, CDH13, JUP, PTPRM |
| MF | GO:0050839 | cell adhesion molecule binding | 0.001248405 | 0.001113019 | FN1, BAIAP2L1, NDRG1, DAB2IP, CTNND1, PPFIBP1, STXBP6, TJP1, SLC9A3R2, CDH5, CDH13, JUP, PTPRM |
| MF | GO:0098632 | cell-cell adhesion mediator activity | 0.021225025 | 0.018923229 | BAIAP2L1, DSCAML1, STXBP6, JUP |
| MF | GO:0008143 | poly(A) binding | 0.024149341 | 0.021530411 | RBMS3, RBPMS, RBMS2 |
| MF | GO:0098631 | cell adhesion mediator activity | 0.024149341 | 0.021530411 | BAIAP2L1, DSCAML1, STXBP6, JUP |
| MF | GO:0070717 | poly-purine tract binding | 0.03512892 | 0.031319284 | RBMS3, RBPMS, RBMS2 |
| MF | GO:0071813 | lipoprotein particle binding | 0.03512892 | 0.031319284 | LPL, GPIHBP1, CDH13 |
| MF | GO:0071814 | protein-lipid complex binding | 0.03512892 | 0.031319284 | LPL, GPIHBP1, CDH13 |