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LIM homeobox 5 (LHX5) and T cell leukemia homeobox 1 (TLX1) were downregulated in the recurrent GBM tissues and exhibited high diagnostic value. (a) Immunohistochemical (IHC) staining was used to determine the expression of LHX5 and TLX1 in the recurrent GBM tissues and primary GBM tissues. (b) Receiver operating characteristic (ROC) analysis was performed to determine the diagnostic value of LHX5 and TLX1 in distinguishing between the recurrent and primary GBM tissues
