Table 3.
GO analysis of DEGs in PAH
| Category | Term | Count | P-value | FDR |
|---|---|---|---|---|
| BP | neutrophil chemotaxis | 10 | 1.94E-08 | 2.62E-05 |
| BP | inflammatory response | 19 | 5.34E-08 | 3.61E-05 |
| BP | positive regulation of smooth muscle cell proliferation | 8 | 2.28E-06 | 1.03E-03 |
| BP | cell chemotaxis | 8 | 3.94E-06 | 1.33E-03 |
| BP | positive regulation of inflammatory response | 8 | 8.61E-06 | 2.33E-03 |
| CC | extracellular space | 47 | 1.54E-14 | 2.73E-12 |
| CC | extracellular region | 48 | 2.31E-12 | 2.04E-10 |
| CC | cell surface | 19 | 4.97E-06 | 2.93E-04 |
| CC | extracellular exosome | 48 | 6.73E-05 | 2.98E-03 |
| CC | extracellular matrix | 11 | 5.97E-04 | 2.11E-02 |
| MF | integrin binding | 9 | 1.04E-05 | 2.26E-03 |
| MF | 3ʹ,5ʹ-cyclic-AMP phosphodiesterase activity | 5 | 1.21E-05 | 2.26E-03 |
| MF | calcium ion binding | 20 | 1.05E-04 | 1.31E-02 |
| MF | heparin binding | 8 | 1.15E-03 | 8.01E-02 |
| MF | growth factor activity | 8 | 1.24E-03 | 8.01E-02 |
Note: GO, Gene Ontology; DEGs, differentially expressed genes; PAH, Pulmonary arterial hypertension; BP, biological process; CC, cellular component; MF, molecule function; FDR, false discovery rate