Table 2.

Correlation of SMAD gene expression level with overall survival (OS) of gastric cancer patients with different differentiation

SMADs	Differentiation	Cases	HR (95% CI)	P-value
SMAD1	Poor	121	1.51 (0.91 − 2.5)	0.11
	Moderate	67	0.5 (0.25 − 1.01)	0.048*
	Well	32	Not available	Not available
SMAD2	Poor	165	1.22 (0.81 − 1.85)	0.34
	Moderate	67	0.59 (0.29 − 1.18)	0.13
	Well	32	0.6 (0.25 − 1.42)	0.24
SMAD3	Poor	165	1.26 (0.82 − 1.95)	0.29
	Moderate	67	2.45 (1.22 − 4.93)	0.0099*
	Well	32	3.97 (0.92 − 17.13)	0.047*
SMAD4	Poor	165	0.81 (0.53 − 1.24)	0.34
	Moderate	67	0.5 (0.25 − 1.02)	0.054
	Well	32	0.35 (0.14 − 0.89)	0.021*
SMAD5	Poor	165	0.81 (0.55 − 1.21)	0.31
	Moderate	67	1.74 (0.8 − 3.82)	0.16
	Well	32	0.47 (0.19 − 1.15)	0.09
SMAD6	Poor	165	1.64 (1.1 − 2.44)	0.014*
	Moderate	67	0.6 (0.28 − 1.28)	0.18
	Well	32	0.55 (0.23 − 1.31)	0.17
SMAD7	Poor	165	1.62 (1.08 − 2.45)	0.019*
	Moderate	67	2.08 (0.85 − 5.13)	0.1
	Well	32	2.72 (0.8 − 9.27)	0.097
SMAD9	Poor	121	1.42 (0.82 − 2.43)	0.21
	Moderate	67	1.81 (0.79 − 4.14)	0.15
	Well	32	Not available	Not available

*P < 0.05

Abbreviations: CI, confidence interval; HR, hazard ratio.