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. 2021 Jun 15;12(1):2563–2575. doi: 10.1080/21655979.2021.1935525

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — KAT2B expression was negatively regulated by miR-93-5p

(a) UpSet plot of miRNAs differentially expressed using five independent databases. (b) Bioinformatics database prediction of the binding site of miR-93-5p on the KAT2B 3'-UTR. (c) Relative miR-93-5p expression level was determined by qPCR in paired normal and cervical cancer tissues. (d) The expression of miR-93-5p in one normal cervical squamous epithelial cell and four cervical cancer cell lines by qPCR analyses. (e) Western blot analysis of KAT2B protein in cervical cancer cells transfected with miR-93-5p mimics or inhibitor. (f) The correlation between miR-93-5p gene expression and KAT2B expression. (g) Dual-luciferase reporter assay indicated that miR-93-5p binds to KAT2B mRNA 3'UTR directly. (h) Expression levels of EMT-associated markers in cervical cancer cell lines following transfection with miR-93-5p mimics or inhibitor were evaluated by western blot analysis. *p < 0.05, **p < 0.01, ***p < 0.001.