Figure 2.

CPT1C overexpression attenuated cell viability and toxic injury in Aβ_25-35-induced HT22 cells. HT22 cells were transfected with Ov-CPT1C or Ov-NC for 24 h, and then treated with Aβ_25–35 for another 24 h

(a) mRNA and protein expressions of CPT1C were measured using RT-qPCR and western blot, respectively. ***P < 0.001 vs Ov-NC. (b) The cell viability of Aβ_25-35-induced HT22 cells was detected using CCK-8. ***P < 0.001 vs. Control group, ^##P < 0.01 vs Aβ_25-35 + Ov-NC. (c) The relative LDH level of Aβ_25-35-induced HT22 cells was checked using LDH assay. ***P < 0.001 vs. Control group, ^###P < 0.001 vs Aβ_25-35 + Ov-NC.