Table 1.
The expression of 8 DEmiRNAs in probiotic environment from TCGA and GEO database
| miRNA | TCGA (colorectal cancer vs normal) |
GEO (with probiotics VS without probiotics) |
Role | |||
|---|---|---|---|---|---|---|
| LogFC | FDR | LogFC | P.value | Group Set | ||
| hsa-mir-429 | 4.114057 | 1.62E-19 | −3.31806 | 0.01654 | LGG VS control | Oppose |
| hsa-mir-141 | 5.414177 | 7.61E-42 | 3.056937 | 0.021687 | LGG+ B.caccae VS control | Support |
| hsa-mir-140 | −1.31675 | 3.01E-08 | 3.03569 | 0.022295 | LGG+ B.caccae VS control | Opposite |
| hsa-mir-22 | 2.181122 | 9.85E-14 | 2.735955 | 0.033153 | LGG+ B.caccae VS control | Support |
| hsa-mir-132 | −1.35959 | 9.53E-08 | 2.810566 | 0.030002 | LGG+ B.caccae VS control | Oppose |
| hsa-mir-454 | 6.098412 | 3.47E-22 | 3.601023 | 0.010924 | LGG+ B.caccae VS control | Support |
| 3.342003 | 0.016062 | LGG VS control | Support | |||
| hsa-mir-153 | 5.705182 | 3.50E-05 | −2.77244 | 0.03157 | LGG+ B.caccae VS control | Oppose |
| hsa-mir-143 | 3.623069 | 4.96E-08 | 3.097131 | 0.02177 | LGG VS control | Support |
Control group, without bacteria; FDR, false discovery rate; FC, fold change; Role, the role of probiotics on colorectal carcinogenesis and tumor progression; LGG, Lactobacillus rhamnosus GG; B.caccae, Bacteroides caccae