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PI3K/AKT/mTOR signaling was drastically suppressed by icariin. Western blotting was used to determine the protein levels of PI3K, p-AKT1, AKT1, p-mTOR, mTOR, p70S6K, and p-p70S6K in treated chondrocytes. PI3K, p-AKT1/AKT1, p-mTOR/mTOR, and p70S6K/p-p70S6K levels were significantly decreased in the rapamycin and icariin groups and increased in the 3-methyladenine group (**p < 0.01 vs. Control). Data are presented as means ± SD (n = 6)
