Figure 5.

Overexpression of miR-6734-3p sensitized NSCLC cells to cisplatin treatment. The CS-NSCLC and CR-NSCLC cells were challenged by high-dose cisplatin. (a, b) Cell proliferation was determined by CCK-8 assay. (c) FCM was performed to examine cell apoptosis. (d) Downregulated miR-6734-3p, and (e, f) upregulated ZEB2 were observed in CR-NSCLC cells, in contrast with the corresponding CS-NSCLC cells. (g, h) Cisplatin-induced inhibition of NSCLC cell proliferation was enhanced by miR-6734-3p overexpression and ZEB2 ablation. (i) Targeting miR-6734-3p and ZEB2 increased cell apoptosis ratio in CR-NSCLC cells stimulated by high-dose cisplatin. Individual experiment had 3 repetitions, and *P < 0.05