Table 1.
Baseline characteristics of studies included in the meta-analysis
| Study | Origin | Cancer Type | Cases (low/high) | Gender (male/female) | Tumor stage | Median age (range) | Test method | Definition of high or low CD169+ macrophages | Location | Survival results | Maximum months of follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Asano 2018 | Japan | Bladder cancer | 44 (26/18) | 35/9 | TNM (I–IV) | 70 (49–85) | IHC | Mean number of cells and mean intensity | Regional lymph nodes | OSMA | 133 |
| Hiroto 2018 | Japan | Esophageal cancer | 182 (101/81) | 160/22 | TNM (I–IV) | NA | IHC | Mean densities | Regional lymph nodes | OSMA | 140 |
| Li 1# 2017 | China | Hepatocellular carcinoma | 188 (94/94) | 156/29 | TNM (I–III) | 50 (13–76) | IHC | Mean densities | Intra-tumor | OSMA | 120 |
| Li 2# 2017 | China | Gastric cancer | 132 (66/66) | 95/37 | TNM (I–IV) | 69 (28–78) | IHC | Mean densities | Intra-tumor | OSMA | 120 |
| Ohnishi 2013 | Japan | Colorectal carcinoma | 83 (45/38) | 48/35 | TNM (I–IV) | 64 (29–90) | IHC | Mean number of cells | Regional lymph nodes | OSUA | 100 |
| Ohnishi 2016 | Japan | Endometrial carcinoma | 79 (39/40) | NA | FIGO (I–IV) | 59 (30–74) | IHC | Mean number of cells | Regional lymph nodes | OSUA | 120 |
| Saito 2015 | Japan | Melanoma | 84 | 36/48 | Stage (0–4) | 69 (34–91) | IHC | Mean number of cells | Regional lymph nodes | OSMA | 100 |
| Shiota 2016 | Japan | Breast Cancer | 146 | 73/73 | Stage (1–3) | 56 (NA) | IHC | Mean number of cells | Regional lymph nodes | OSMA, RFSMA | 159 |
| Strömvall 2017 | Sweden | Prostate cancer | 109 (27/82) | NA | Gleason (6–9) | NA | IHC | Mean densities | Regional lymph nodes | OSMA | 250 |
| Wang 2015 | China | Bladder carcinoma | 302 (151/151) | 262/40 | TNM (0-IV) | 60 (15–90) | IHC | Mean number of cells and mean intensity | Intra-tumor | OSMA | 82 |
| Zhang 2016 | China | Hepatocellular carcinoma | 328 (164/164) | 292/36 | TNM (I–III) | 48 (20–78) | IHC | Mean densities | Intra-tumor | OSMA | 96 |
This means that these two different studies are from the same article.
Abbreviations: NA, not available; IHC, immunohistochemistery; OS, overall survival; RFS, recurrence-free survival; MA, multivariate analysis; UA, univariate analysis.