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Limonin attenuates the Nrf2 and Sirt2 signaling inactivated by DOX. (a) The protein expression of Nrf2 and Sirt2, and their downstream effectors was examined in H9C2 cells with or without DOX treatment plus limonin or not. DOX: 1 μM, Limonin: 5 μM. (b) The protein expression of Nrf2 and Sirt2, and their downstream effectors was examined in heart tissues from rat treated differently as indicated. DOX: 10 mg/kg, Limonin: 10 mg/kg
