Figure 1.

The hsa_circ_0005567 expression and macrophage polarization in synovial tissue of osteoarthritis patients.Synovial tissues of 15 patients with osteoarthritis (OA group) and 15 patients with fracture or osteosarcoma who underwent knee arthroplasty or amputation without osteoarthritis clinical symptoms (control group) were collected. The total RNA of each synovial tissue was extracted by Trizol. A. The hsa_circ_0005567 expression was significantly decreased in synovial tissue of the osteoarthritis group. B. The expression of M1 type macrophage markers were upregulated, while the expression of M2 type macrophage markers were downregulated in synovial tissue of the osteoarthritis group. **p < 0.01 vs Control group