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Circ_0054537 deletion retarded tumor growth of RCC in nude mice by regulating miR-640 and NPTX2. (a) Tumor volume in xenograft mice was monitored every week for 4 weeks. (b) Tumor weight was examined, (c, d) RT-qPCR detected circ_0054537 and miR-640 expression, (e) western blotting examined NPTX2 expression, and (f, g) western blotting and/or IHC measured expression of MMP-9, Bax and ki-67 in xenograft mice after 4 weeks. ***P < 0.001
