Table 3.
Univariate and multivariate Cox regression analyses of DFS in HCC patients
| Parameter | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Gender (vs. male) | 1.257 (0.544–2.901) | 0.592 | ||
| Age | 0.673 (0.430–1.053) | 0.083 | ||
| Tumor size | 1.348 (0.972–1.869) | 0.073 | ||
| Capsule invasion | 1.880 (0.809–4.366) | 0.142 | ||
| Lymphovascular infiltration | 1.662 (0.852–3.240) | 0.136 | ||
| Differentiation degree | 0.962 (0.576–1.605) | 0.882 | ||
| Cirrhosis | 1.710 (0.927–3.153) | 0.086 | ||
| T stage | 1.413 (1.016–1.966) | 0.040 | 1.184 (0.682–2.055) | 0.549 |
| N stage | 2.226 (1.303–3.800) | 0.003 | 1.498 (0.664–3.379) | 0.330 |
| TNM stage | 1.542 (1.142–2.081) | 0.005 | 1.121 (0.660–1.904) | 0.672 |
| AFP | 3.133 (1.962–5.002) | < 0.001 | 2.339 (1.330–4.111) | 0.003 |
| Ki67 | 1.417 (0.921–2.181) | 0.113 | ||
| EWSR1 overexpression | 3.177 (1.947–5.185) | < 0.001 | 1.654 (1.098–3.011) | 0.041 |
Abbreviations: AFP, alpha-fetoprotein; CI, coefficient interval; DFS, disease-free survival; HCC, Hepatocellular carcinoma; HR, hazard ratio; N, nodule; T, tumor; TNM; tumor-nodule-metastasis.