Figure 2.

Exosomal miR-17-3p attenuated H₂O₂-induced programmed necrosis in primary cardiomyocytes in vitro. (a) miR-17-3p expression was measured by qRT-PCR in primary cardiomyocytes treated with peripheral blood exosomes (n = 3) using U6 as the control gene. (b, c) Necrotic cell death was assessed using PI staining following treatment with peripheral blood exosomes or the miR-17-3p inhibitor (n = 3). The representative images show the PI-positive cells (bar = 100 μm). Data are presented as the mean ± SD; ^∗P < 0.05; ^∗∗∗∗P < 0.001.