Figure 5.

Exosomal miR-17-3p greatly alleviated cardiac I/R injury. (a) miR-17-3p expression was measured by qRT-PCR. (b) LVEDd, LVEDs, and EF of the left ventricle and fractional shortening (FS) at the left ventricular short axis after cardiac I/R injury were evaluated by echocardiography. (c) The effects of the exosomes and miR-17-3p inhibitor on the infarct size were determined by TTC staining.(d, e) The effect of exosomal miR-17-3p on inflammatory cell infiltration and fibrosis was investigated using H&E and Masson staining, respectively (bar = 100 μm). Data are presented as the mean ± SD (n = 3); ^∗∗P < 0.01; ^∗∗∗P < 0.001; ^∗∗∗∗P < 0.0001.