Figure 1.

PP2A regulates heterochromatin localization and prevents euchromatic gene expression. (A) PP2A dephosphorylates heterochromatin-bound PRR14 to allow HP1–PRR14 interaction and sequestration of heterochromatin to the nuclear lamina. (B) PP2A dephosphorylates free nucleoplasmic Lamins to promote Lamin polymerization at the nuclear periphery. (C) CIP2A and MYC bind nuclear pore proteins to promote the rapid expression of MYC-dependent genes within associated euchromatin. CIP2A is a known inhibitor of PP2A activity, thereby repressing the ability of PP2A to regulate MYC.