Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 1;4(1):zcac002. doi: 10.1093/narcan/zcac002

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — PP2A regulates proteins that contribute to acetylation and methylation of epigenetic targets. (A) PP2A dephosphorlates BRD4, preventing BRD4 from binding to acetylated residues and promoting gene transcription. (B) PP2A dephosphorylates HDAC 4/5/7 and prevents 14-3-3 binding, allowing HDAC nuclear localization and subsequent deacetylation of histones. (C) High PP2A activity is correlated with low PRMT1/5 methylase activity at the H4R3me2 methylation site. The impact of this regulation on gene transcription is cancer dependent. (D) PP2A dephosphorylates TET2 and reduces TET2 stability. This action antagonizes efficient methylcytosine removal.