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PP2A contributes to regulation of transcription as part of the Integrator-PP2A (INTAC) complex. The PP2A A/C subunits bind to the Integrator complex and promote dephosphorylation of S2/5/7 residues on the tail of RNA Polymerase II in addition to SPT5. These actions prevent efficient transcriptional initiation and elongation of RNA transcripts. INTAC dephosphorylation of RNA Polymerase II and SPT5 is counteracted by CDK9 phosphorylation.
