Table 1.
Epigenetic targets of PP2A.
| PP2A Target | Associated B-Subunit | S/T Residue | Opposing Kinase(s) | Effect of Dephosphorylation | References |
|---|---|---|---|---|---|
| PRR14 | B56a contains SLIM motif and may interact with other B56 family members | S242, T266, T270, S277 | Not determined | Promotion of proper localization of heterochromatin to nuclear periphery | (39) |
| H3 | Not determined | S10 | AURKA, AURKB, IKKα, JNK, AKT1, MAP3K8, MSK1/2, PIM1 | Decreased output of MYC and MYC-related gene targets; Decrease in cell proliferation | (54,57,185) |
| Lamin A/C | Possibly B56 family members as phosphorylation status changes in response to CIP2A expression | S22, S628 | CDK1/CyclinB | Head-to-tail polymerization of Lamin A/C, proper Lamin distribution at nuclear envelope | (41–43) |
| BRD4 | Not determined | S484/S488 | CK2 | Nuclear localization; Negative regulation of BRD4-associated gene transcription | (68,69) |
| SWI/SNF | Possibly B55α, only identified in C. elegans | Not determined | ERK1 | Activation of SWI/SNF complex activity, Mitotic Exit | (186,187) |
| HDAC2 | Not determined | S394 | CK2α1 | Negative regulation of hypertrophic response in cardiomyocytes | (188) |
| HDAC4 | B55α | S298, S246, S467, S632 | PKCϵ, SIK1, SIK2, CaMKII, PKD | Negative regulation of interaction with 14-3-3; Nuclear import of HDAC4; Fibroblast differentiation; Increased glucose uptake; amelioration of neuropathic allodynia; promotes neuronal apoptosis | (76,95,101,189–194) |
| B56 | Not determined | Not determined | Ensures proper chromosomal segregation during mitosis in p53-null cells | (77) | |
| HDAC5 | B55α | S259, S279, S498 | SIK1, CaMKII, PKD, PRK1 | Nuclear localization; Negative regulation of interaction with 14-3-3 | (78,81,189,193–196) |
| HDAC7 | B55α | S155, S181, S321, S449 | PRK1 | Negative regulation of interaction with 14-3-3; Proper endothelial vessel formation | (75,80,196) |
| PRMT1 | Not determined | S297 | Not determined | Inhibition of PRMT1 activity; Decreased methylation of H4 (H4R3me2); HBV-mediated inhibition of INF-α response | (113–115,197) |
| PRMT5 | Not determined | S355 | Not determined | Inactivation of PRMT5 methyltransferase activity | (120) |
| H2A.X | B56ϵ | S129 | ATM | Antagonizes DNA damage repair initiation; promotes DNA damage resolution | (115,116,198,199) |
| TET2 | B55α | S99 | AMPK | Antagonize stability of TET2 | (128) |
| RNA Pol II | Integrator INTS8, INTS6 | S2, S5, S7 | CDK9 | Negative regulation of transcriptional initiation and elongation | (131,132) |
| SPT5 | Integrator INTS8 | S666 | CDK7, CDK9 | Impaired ‘pause, release’ mechanism of RNA Pol II | (141) |