Table 4.

Results before removal of M3 (T0) compared with one day (T1), three days (T2), seven days (T3) and one month (T4)

	Cryotherapy	T1-T0				T2-T0				T3-T0				T4-T0
		Estimate	95% CI	SE	P	Estimate	95% CI	SE	P	Estimate	95% CI	SE	P	Estimate	95% CI	SE	P
Pain	without cryotherapy	Reference	-	-	-	Reference	-	-	-	Reference	-	-	-	Reference	-	-	-
	with cryotherapy	11.15	0.72; 21.57	5.32	< 0.05	6.87	-0.91; 14.66	3.971	0.083	-7.07	-15.34; 1.19	4.216	0.093	7.5	-5.23; 20.23	6.495	0.248
Trismus	without cryotherapy	Reference	-	-	-	Reference	-	-	-	Reference	-	-	-	Reference	-	-	-
	with cryotherapy	-	-	-	-	-1.4	-6.41; 3.61	2.554	0.584	3.68	-0.87; 8.23	2.321	0.113	1.45	-12.38; 15.28	7.054	0.837

CI = confidence interval; M3 = mandibular third molar; SE = standard error; VAS = visual analog scale.

Third molars allocated to no cryotherapy were used as reference for the group with cryotherapy.

Pain: assessed by VAS. Estimated value reveals differences in VAS score of pain in millimetres with cryotherapy compared with no cryotherapy.

Trismus: assessed by a ruler. Estimated value shows how many mm the incisal distance has increased or decreased compared to no cryotherapy.

Mean difference in pain and trismus were analyzed with a generalized estimating equation (GEE) analysis for repeated observations.