TABLE 1.
Relationship between clinicopathological characteristics and ASCL1/DLL3 expressions
Characteristics | Patients (N = 247) | ASCL1 expression | p value | DLL3 expression | p value | ||
---|---|---|---|---|---|---|---|
Low (%) | High (%) | Low (%) | High (%) | ||||
Gender | |||||||
Male | 175 | 101(71) | 74(70) | 1.00 | 44(75) | 131(70) | 0.52 |
Female | 72 | 41(29) | 31(30) | 15(25) | 57(30) | ||
Age | |||||||
≤65 | 202 | 115(81) | 87(83) | 0.74 | 48(81) | 154(82) | 1.00 |
>65 | 45 | 27(19) | 18(17) | 11(19) | 34(18) | ||
Smoking | |||||||
Yes | 158 | 90(63) | 68(65) | 0.89 | 41(69) | 117(62) | 0.35 |
No | 89 | 52(37) | 37(35) | 18(31) | 71(38) | ||
Tumor location | |||||||
Left lung | 122 | 74(52) | 48(46) | 0.37 | 35(59) | 87(46) | 0.10 |
Right lung | 125 | 68(48) | 57(54) | 24(41) | 101(54) | ||
Clinical stage | |||||||
I | 78 | 47(33) | 31(30) | 0.02* | 21(36) | 57(30) | 0.28 |
II | 68 | 47(33) | 21(20) | 19(32) | 49(26) | ||
III | 101 | 48(34) | 53(50) | 19(32) | 82(44) | ||
Vascular tumor thrombus | |||||||
Yes | 125 | 76(54) | 49(47) | 0.31 | 35(59) | 87(46) | 0.10 |
No | 122 | 66(46) | 56(53) | 24(41) | 101(54) | ||
Pleural invasion | |||||||
Yes | 170 | 91(64) | 79(75) | 0.07 | 42(71) | 128(68) | 0.75 |
No | 77 | 51(36) | 26(25) | 17(29) | 60(32) | ||
Lymph node metastasis | |||||||
Yes | 143 | 75(53) | 68(65) | 0.07 | 28(47) | 115(61) | 0.07 |
No | 104 | 67(47) | 37(35) | 31(53) | 73(39) | ||
Bronchus invasion | |||||||
Yes | 210 | 119(84) | 91(87) | 0.59 | 50(85) | 160(85) | 1.00 |
No | 37 | 23(16) | 14(13) | 9(15) | 28(15) | ||
Vascular invasion | |||||||
Yes | 206 | 117(82) | 89(85) | 0.73 | 44(75) | 162(86) | 0.045* |
No | 41 | 25(18) | 16(15) | 15(25) | 26(14) | ||
Nerve invasion | |||||||
Yes | 84 | 40(28) | 44(42) | 0.03* | 18(31) | 66(35) | 0.64 |
No | 163 | 102(72) | 61(58) | 41(69) | 122(65) | ||
STAS | |||||||
Yes | 182 | 104(73) | 78(74) | 0.89 | 40(68) | 142(76) | 0.24 |
No | 65 | 38(27) | 27(26) | 19(32) | 46(24) | ||
Necrosis proportion | |||||||
≤30% | 172 | 97(68) | 75(71) | 0.68 | 37(63) | 135(72) | 0.20 |
>30% | 75 | 45(32) | 30(29) | 22(37) | 53(28) | ||
Fibrosis proportion | |||||||
≤10% | 116 | 75(53) | 41(39) | 0.04* | 30(51) | 86(46) | 0.55 |
>10% | 131 | 67(47) | 64(61) | 29(49) | 102(54) | ||
TILs | |||||||
≤30% | 212 | 124(87) | 88(84) | 0.46 | 49(83) | 163(87) | 0.52 |
>30% | 35 | 18(13) | 17(16) | 10(17) | 25(13) |
p value <0.05.