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. 2021 Dec 31;4(1):vdab192. doi: 10.1093/noajnl/vdab192

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Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology 2021.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 6. — Using a leave-one out compound validation approach, only genes with reversal designation present in every trial with P < .25 were kept to create a list of reversed genes for (A) CLA, (B) MES, (C) PRO. Green means upregulated and red means downregulated regarding the compound's effect on the gene. Effective compounds have IC₅₀ < 10 μM, and ineffective have IC₅₀ >= 10 μM.