Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 26;16(3):764–779. doi: 10.1002/1878-0261.13107

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 1 — Expression of SSTR5 is regulated by DNA methylation and NAT. (A) Cartoon representation of SSTR5‐AS1 and SSTR5 loci, based on Genome Browser information. (B) Comparison of methylation levels between somatotropinoma (SOMAT) and normal pituitary (NP) samples, expressed as percentage, under t test. (C) Expression levels of SSTR5 and SSTR5‐AS1 (t test) and (D) correlations (Pearson correlation) between them in somatotropinomas and NPs, measured by qPCR and normalized by ACTB. (E) Correlations (Pearson correlation) between methylation levels of CpG4.3 and expression levels of SSTR5 and SSTR5‐AS1 in somatotropinoma samples. (F) Expression levels of SSTR5 and SSTR5‐AS1 (Mann–Whitney U test) and (G) correlations (Spearman correlation) between them in PanNETs and nontumor adjacent tissue (NTAT), measured by qPCR and normalized by RNA18S1. Asterisks (*P < 0.05; ***P < 0.001) indicate values that significantly differ from control. In all cases, data represent median and interquartile range of 27 somatotropinomas, 11 NPs and 15 PanNETs with their NTAT.