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. 2021 Aug 31;36(2):370–382. doi: 10.1038/s41375-021-01392-1

Fig. 1. PHF6 mutations are associated with JAK3 mutations in AL patients.

Fig. 1

A, B The percentage of JAK3 or PHF6 mutations in 449 T-ALL patients from three independent clinical centers. C Left panel, the frequency of PHF6 mutations (orange) in T-ALL patients with JAK3 mutations vs the frequency of PHF6 mutations in T-ALL patients with WT JAK3. Right panel, the frequency of JAK3 mutations (orange) in T-ALL patients with PHF6 mutations vs the frequency of JAK3 mutations in T-ALL patients with WT PHF6. Fisher’s exact test was applied to calculate the P values to analyze the significance of the positive association between JAK3 mutations and PHF6 mutations. D Frameshift (fs), nonsense (non), and missense (mis) of PHF6 or JAK3 found in 44 T/M MPAL cases from Alexander et al. [19]. Each type of mutation is indicated by a unique color. Gender are also shown for each patient. E Total case number, median age, gender ratio, mutation type and average survival time of 44 T/M MPAL patients from Alexander et al. [19].