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. 2022 Jan 18;12:699535. doi: 10.3389/fphar.2021.699535

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Copyright © 2022 Hunziker, Reinehr, Palmhof, Wagner, Biniasch, Stute, Mattei, Schmitz, DiGiorgio, Hert, Rudolph, Benz, Stihle, Gsell, Müller, Gasser, Schonhoven, Ullmer and Joachim.

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Plasma LPA profiles in rat (PK/PD). (A) Dose and free exposure dependent lowering of total basal plasma LPA in vivo in rat at 1, 3, 6, and 24 h after dosing with 13, normalized to the vehicle control. For all doses (3, 10, and 30 mg/kg po), 5 animals/group were used. (B) Inhibition of the formation of 4 different LPA species in rat plasma after a single oral dose of 13 (10 mg/kg, n = 5) at the same time points, normalized to the vehicle control (LPA formation was measured after incubation of the plasma samples at 37°C for 2 h). Values are mean ± SD.