TABLE 2.

Pharmacokinetic data in rats. (A) Intravenous bolus administration for compound 7, 13, 14, and 15. (B) Oral administration for compound 7, 13, 14, 15 by gavage and food admix for compound 13. Abbreviations: AUC: area under the curve; CLp: plasma clearance; n: number of animals; FA: food admix; Oral F: oral bioavailability; T1/2: half-life; Tmax: time to maximal concentration; Vdss, volume of distribution.

A
Compound	Dose (mg/kg)	N	CLp (ml/min/kg)	Vdss (L/kg)	T1/2 (h)	AUC(0-inf) (hr*ng/mL)
14	3	2	47	0.9	1.3	1,070
13	2	3	1.6	0.3	2.6	21,000
7	3	2	23	1.3	0.8	2,140
15	3	2	156	1.7	0.35	321

B
Compound	Dose (mg/kg)	N	Cmax (ng/ml)	Tmax (h)	AUC(0-inf) (hrs*ng/mL)	T1/2 (h)	Oral F (%)
14	30	3	130	0.5	660	3.8	6
13	10	2	17,690	0.75	130,000	4.6	80
13 (FA)	20	3	2,980	17	260,000	13	80
7	20	2	2,500	0.25	7,900	1.6	54
15	30	3	18	0.25	30	1.9	1.1

Bold values in this table are referring to the compound identifiers, which are kept in bold throughout the manuscript.