TABLE 4.
Data of ATX-inhibitors with benzotriazole ZBG and trans-octahydropyrrolopyrrole core. A clearance value of 10 μL/m/mg prot indicates a low microsomal clearance, which is essentially below the detection limit of the assay.
| |||||||
|---|---|---|---|---|---|---|---|
| Cmpd | R | hATX IC50 [nM] | LogD (pH 7.4) | Solubility [µg/mL], pH 6.5 | Permeability Pe [10–6 * cm/s] | Mic CL h/m/r [µL/m/mg prot] | GSH adducts |
| 11 |
|
1 | 2.3 | <1 | Na | 10/10/na | Neg |
| 12 |
|
137 | 3.2 | 8 | 1.8 | 10/na/10 | Neg |
| 13 |
|
6 | 3.2 | 28 | 4.5 | 10/10/10 | Neg |
| 14 |
|
6 | 2.5 | 46 | 2.7 | 10/27/40 | Neg |
| 15 |
|
8 | 2.0 | 190 | 0.4 | 10/10/na | Neg |
Na = not available.