Fig. 6.

Anlotinib restraints GBM growth in vivo. a Representative bioluminescent images showed tumor volumes in orthotopic GBM model at 7, 14 and 28 days. b Quantification of tumor volumes in the different treatment arms. c Representative images of IHC staining of Ki-67. d Tumor tissues from two different nude mice in each treatment group were analyzed by western blotting. The relative tumor volumes of the control group were adjusted to the value of 1. Data were represented as means ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 vs control group