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. 2022 Jan 19;12:827256. doi: 10.3389/fimmu.2021.827256

Figure 2.

Figure 2

Fel d 1-specific antibody responses of WT and TLR7 KO mice upon QβRNA-Fel d 1 immunization. (A) Immunization scheme. three mice per group were injected with 30 μg QβRNA-Fel d 1 or Fel d 1 in PBS at d0, and mice were bled at d7, 14, 21, 28, 35, 42 and 56. Fel d 1-specific antibody titers (B) and avidity indexes (C) in WT and TRL7 KO mice after immunization were demonstrated. IgG subclasses 2b (D), 2c (E) and 1 (F) in WT and TRL7 KO mice after QβRNA-Fel d 1 immunization were determined by ELISA. p value from unpaired t-test was indicated as ≤0.05 (*), ≤0.01 (**), ≤0.001 (***). The figure is representative of two independent experiments.