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. 2022 Jan 19;12:827256. doi: 10.3389/fimmu.2021.827256

Figure 4.

Figure 4

Antibody responses of bone marrow chimeric mice against Fel d 1 after QβRNA-Fel d 1 immunization. (A) Immunization scheme. Irradiated mice were reconstituted with 80% JH KO and 20% WT or 20% TLR7 KO BM cells. Three mice per group were injected subcutaneously with 30 μg QβRNA-Fel d 1 at d0, and mice were bled at d4, 6, 9, 12, 15, and 21. Total Fel d 1-specific IgG antibody titers (B), avidity indexes (C) and IgG2b (D), IgG2c (E) and IgG1 (F) antibody titers of WT and KO chimeras after QβRNA-Fel d 1 immunization were determined by ELISA. p value from unpaired t-test was indicated as ≤0.05 (*), ≤0.01 (**), ≤ 0.0001 (****). The figure is representative of two independent experiments.